Hotels in Southeast Missouri, Missouri

  • Overview

    Southeast Missouri is a region located in the southeastern part of the state of Missouri, United States of America. Known for its charming small towns, scenic landscapes, and rich history, this area offers a unique and diverse experience to visitors.

  • When to visit

    The best time to visit Southeast Missouri is during the spring and fall seasons when the weather is mild and pleasant. Springtime brings blooming flowers and lush greenery, making it a perfect time for outdoor activities and exploring nature. Fall, on the other hand, offers stunning foliage colors, creating a picturesque setting for hiking, biking, and sightseeing. However, each season in Southeast Missouri has its own charm, so visitors can find enjoyable experiences throughout the year.

  • Reasons to Visit

    There are several reasons to visit Southeast Missouri. One of the main attractions in the region is the beautiful Shawnee National Forest, where visitors can explore numerous hiking trails, stunning rock formations, and picturesque waterfalls. The region is also home to historic sites such as the Bollinger Mill State Historic Site and the Trail of Tears State Park, providing insights into the area's past. Additionally, Southeast Missouri is renowned for its quaint wineries and vineyards, allowing visitors to indulge in wine tasting tours and enjoy the serene countryside. The region also hosts various festivals and cultural events throughout the year, providing a vibrant and festive atmosphere.

  • Nearby Attractions

  • Shawnee National Forest

    Shawnee National Forest is a natural wonderland that spans across Southern Illinois and Southeast Missouri. It boasts numerous hiking trails, breathtaking rock formations like Garden of the Gods, and cascading waterfalls such as Jackson Falls.

  • Bollinger Mill State Historic Site

    The Bollinger Mill State Historic Site is a restored mill and covered bridge that offers a glimpse into the region's past. Visitors can tour the mill, learn about the milling process, and explore the scenic surroundings.

  • Trail of Tears State Park

    The Trail of Tears State Park commemorates the forced relocation of Native American tribes in the 19th century. It features interpretive exhibits, hiking trails, and scenic views of the Mississippi River.

  • Southeast Missouri Wine Trail

    The Southeast Missouri Wine Trail comprises multiple wineries and vineyards that offer tastings and tours. Visitors can savor a variety of wines while enjoying the stunning landscapes and warm hospitality of the region.

  • Annual Events and Festivals

    Southeast Missouri hosts various annual events and festivals that celebrate the region's culture and heritage. These include the Sikeston Jaycee Bootheel Rodeo, Cape Girardeau Heritage Days, and numerous fairs and music festivals.

  • Hotels

  • Baymont Inn and Suites by Wyndham Farmington, MO

    - Make yourself at home in one of the 94 air-conditioned guestrooms. Wireless internet access (surcharge) keeps you connected, and cable programming is available for your entertainment. Private bathroom Next available price is 58.20 on Sept. 17, 2025. Baymont Inn and Suites by Wyndham Farmington, MO

  • Best Western Plus Sikeston

    - Make yourself at home in one of the 55 air-conditioned rooms featuring microwaves and MP3 docking stations. 42-inch LCD televisions with cable programming provide entertainment, while wireless interne Next available price is 90.62 on Sept. 17, 2025. Best Western Plus Sikeston

  • Candlewood Suites Cape Girardeau, an IHG Hotel

    - Make yourself at home in one of the 85 air-conditioned rooms featuring kitchens with full-sized refrigerators/freezers and stovetops. 32-inch LCD televisions with cable programming provide entertainme Next available price is on . Candlewood Suites Cape Girardeau, an IHG Hotel

  • Comfort Inn & Suites Sikeston I-55

    - Make yourself at home in one of the 64 air-conditioned guestrooms. Complimentary wireless internet access is available to keep you connected. Bathrooms with bathtubs or showers are provided. Convenien Next available price is 93.20 on Sept. 17, 2025. Comfort Inn & Suites Sikeston I-55

  • Comfort Inn Festus - St Louis South

    - Make yourself at home in one of the 90 guestrooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for your entert Next available price is 83.93 on Sept. 17, 2025. Comfort Inn Festus - St Louis South

  • Comfort Inn Poplar Bluff North

    - Make yourself at home in one of the 58 air-conditioned guestrooms. Complimentary wireless internet access is available to keep you connected. Bathrooms with bathtubs or showers are provided. Convenien Next available price is 109.35 on Sept. 17, 2025. Comfort Inn Poplar Bluff North

  • Comfort Suites Jackson-Cape Girardeau

    - Make yourself at home in one of the 64 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available fo Next available price is 87.31 on Sept. 17, 2025. Comfort Suites Jackson-Cape Girardeau

  • Country Yard Inn and Suite

    - Make yourself at home in one of the 35 guestrooms. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms feature showers with Next available price is on . Country Yard Inn and Suite

  • Courtyard by Marriott Cape Girardeau Downtown

    - Make yourself at home in one of the 91 guestrooms featuring refrigerators. Your bed comes with down comforters and Egyptian cotton sheets. Complimentary wired and wireless internet access keeps you co Next available price is 141.55 on Sept. 18, 2025. Courtyard by Marriott Cape Girardeau Downtown

  • Crown Pointe Lodge, BW Signature Collection

    - Make yourself at home in one of the 48 air-conditioned rooms featuring LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertai Next available price is on . Crown Pointe Lodge, BW Signature Collection

  • Current River Inn

    - Make yourself at home in one of the 24 air-conditioned rooms featuring flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your Next available price is on . Current River Inn

  • Days Inn and Suites by Wyndham Sikeston

    - Make yourself at home in one of the 60 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and satellite programming is available Next available price is 66.69 on Sept. 17, 2025. Days Inn and Suites by Wyndham Sikeston

  • Days Inn by Wyndham Perryville

    - Make yourself at home in one of the 65 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for Next available price is 64.13 on Sept. 17, 2025. Days Inn by Wyndham Perryville

  • Drury Inn & Suites Hayti Caruthersville

    - Make yourself at home in one of the 99 guestrooms featuring refrigerators and microwaves. LCD televisions with cable programming provide entertainment, while complimentary wireless internet access kee Next available price is on . Drury Inn & Suites Hayti Caruthersville

  • Drury Inn & Suites Poplar Bluff

    - Make yourself at home in one of the 78 guestrooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your e Next available price is on . Drury Inn & Suites Poplar Bluff

  • Drury Plaza Hotel Cape Girardeau Conference Center

    - Make yourself at home in one of the 168 guestrooms featuring refrigerators and microwaves. LCD televisions with cable programming provide entertainment, while complimentary wireless internet access ke Next available price is on . Drury Plaza Hotel Cape Girardeau Conference Center

  • EC Reed's Mercantile and Hotel

    - Make yourself at home in one of the 14 air-conditioned rooms featuring Smart televisions. Complimentary wireless internet access keeps you connected, and digital programming is available for your ente Next available price is on . EC Reed's Mercantile and Hotel

  • Eagle Inn Charleston

    - Make yourself at home in one of the 19 guestrooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for your entert Next available price is on . Eagle Inn Charleston

  • Econo Lodge

    - Make yourself at home in one of the 49 air-conditioned rooms featuring refrigerators and microwaves. Your room comes with a pillowtop bed. 36-inch LCD televisions with cable programming provide entert Next available price is on . Econo Lodge

  • Fairfield Inn & Suites by Marriott Poplar Bluff

    - Make yourself at home in one of the 84 guestrooms featuring refrigerators and microwaves. LCD televisions with premium TV channels are provided, while complimentary wireless internet access keeps you Next available price is 128.25 on Sept. 17, 2025. Fairfield Inn & Suites by Marriott Poplar Bluff

  • Fort Davidson Hotel

    - Make yourself at home in one of the 22 air-conditioned rooms featuring refrigerators and flat-screen televisions. Complimentary wired and wireless internet access keeps you connected, and cable progra Next available price is on . Fort Davidson Hotel

  • Hampton Inn Cape Girardeau I 55 East

    - Make yourself at home in one of the 86 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wired and wireless internet access keeps you connected, and cable programming provi Next available price is 132.05 on Sept. 17, 2025. Hampton Inn Cape Girardeau I 55 East

  • Hampton Inn Farmington

    - Make yourself at home in one of the 64 guestrooms featuring microwaves and LCD televisions. Your pillowtop bed comes with premium bedding. Complimentary wired and wireless internet access keeps you co Next available price is 224.20 on Sept. 17, 2025. Hampton Inn Farmington

  • Hampton Inn Poplar Bluff

    - Make yourself at home in one of the 79 guestrooms featuring refrigerators and microwaves. Your room comes with a pillowtop bed. Wired and wireless internet access is complimentary, while 39-inch LCD t Next available price is 132.05 on Sept. 17, 2025. Hampton Inn Poplar Bluff

  • Hampton Inn Sikeston

    - Make yourself at home in one of the 92 guestrooms featuring refrigerators and microwaves. Wired and wireless internet access is complimentary, and LCD televisions with premium TV channels provide ente Next available price is 164.35 on Sept. 17, 2025. Hampton Inn Sikeston

  • Hickory House Inn

    - Make yourself at home in one of the 45 air-conditioned rooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available Next available price is on . Hickory House Inn

  • Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

    - Make yourself at home in one of the 72 guestrooms featuring microwaves and flat-screen televisions. Rooms have private furnished balconies or patios. Cable television is provided for your entertainmen Next available price is 213.79 on Sept. 18, 2025. Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel

  • Holiday Inn Express & Suites Farmington, an IHG Hotel

    - Make yourself at home in one of the 60 air-conditioned rooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available Next available price is 216.12 on Sept. 17, 2025. Holiday Inn Express & Suites Farmington, an IHG Hotel

  • Holiday Inn Express & Suites Perryville, an IHG Hotel

    - Make yourself at home in one of the 75 guestrooms featuring refrigerators and LED televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your e Next available price is on . Holiday Inn Express & Suites Perryville, an IHG Hotel

  • Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

    - Make yourself at home in one of the 73 guestrooms featuring refrigerators and microwaves. 42-inch flat-screen televisions with cable programming provide entertainment, while complimentary wireless int Next available price is 170.05 on Sept. 18, 2025. Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel

  • Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

    - Make yourself at home in one of the 102 guestrooms featuring microwaves and flat-screen televisions. Your pillowtop bed comes with down comforters and premium bedding. Complimentary wired and wireless Next available price is 116.81 on Sept. 18, 2025. Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel

  • Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel

    - Make yourself at home in one of the 86 air-conditioned rooms featuring refrigerators and LCD televisions. Cable television is provided for your entertainment. Conveniences include phones, as well as s Next available price is 203.33 on Sept. 19, 2025. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel

  • Holiday Inn Poplar Bluff, an IHG Hotel

    - Make yourself at home in one of the 117 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wired and wireless internet access keeps you connected, and cable programming prov Next available price is 130.38 on Sept. 17, 2025. Holiday Inn Poplar Bluff, an IHG Hotel

  • La Quinta Inn & Suites by Wyndham Festus - St. Louis South

    - Make yourself at home in one of the 57 air-conditioned rooms featuring refrigerators and flat-screen televisions. Complimentary wireless internet access is available to keep you connected. Private bat Next available price is 128.39 on Sept. 19, 2025. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

  • La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

    - Make yourself at home in one of the 80 air-conditioned rooms featuring refrigerators and microwaves. LED televisions with cable programming provide entertainment, while complimentary wireless internet Next available price is 84.66 on Sept. 17, 2025. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

  • Madison Inn Lodge

    - Make yourself at home in one of the 40 air-conditioned rooms featuring refrigerators and microwaves. 43-inch plasma televisions with cable programming provide entertainment, while complimentary wirele Next available price is on . Madison Inn Lodge

  • Microtel Inn & Suites by Wyndham Sainte Genevieve

    - Make yourself at home in one of the 48 individually furnished guestrooms, featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is a Next available price is 94.05 on Sept. 17, 2025. Microtel Inn & Suites by Wyndham Sainte Genevieve

  • Motel 6 Bonne Terre, MO

    - Make yourself at home in one of the 28 air-conditioned rooms featuring microwaves and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is avai Next available price is on . Motel 6 Bonne Terre, MO

  • New Orleans Inn Portageville

    - Make yourself at home in one of the 25 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for Next available price is on . New Orleans Inn Portageville

  • Pear Tree Inn Cape Girardeau Near the Medical Center

    - Stay in one of 78 guestrooms featuring LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with sh Next available price is on . Pear Tree Inn Cape Girardeau Near the Medical Center

  • Pear Tree Inn Cape Girardeau West

    - Make yourself at home in one of the 81 guestrooms featuring refrigerators and LCD televisions. Complimentary wireless internet access is available to keep you connected. Bathrooms have shower/tub comb Next available price is on . Pear Tree Inn Cape Girardeau West

  • Pear Tree Inn Sikeston

    - Make yourself at home in one of the 80 guestrooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your e Next available price is on . Pear Tree Inn Sikeston

  • Quality Inn

    - Make yourself at home in one of the 49 air-conditioned guestrooms. Your memory foam bed comes with down comforters and Egyptian cotton sheets. Complimentary wireless internet access keeps you connecte Next available price is 60.79 on Sept. 17, 2025. Quality Inn

  • Quality Inn Charleston - Sikeston

    - Make yourself at home in one of the 40 guestrooms featuring microwaves and LCD televisions. Complimentary wired and wireless internet access keeps you connected, and cable programming provides enterta Next available price is 65.88 on Sept. 17, 2025. Quality Inn Charleston - Sikeston

  • Quality Inn Farmington

    - Make yourself at home in one of the 48 air-conditioned rooms featuring refrigerators and microwaves. 42-inch LED televisions with cable programming provide entertainment, while complimentary wireless Next available price is 77.89 on Sept. 17, 2025. Quality Inn Farmington

  • Quality Inn Hayti North

    - Make yourself at home in one of the 47 guestrooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for your entert Next available price is 84.55 on Sept. 17, 2025. Quality Inn Hayti North

  • Rockwood Inn

    - Make yourself at home in one of the 7 guestrooms. Complimentary wireless internet access is available to keep you connected. Next available price is on . Rockwood Inn

  • Rosener's Inn and banquet center

    - Make yourself at home in one of the 75 guestrooms. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Next available price is on . Rosener's Inn and banquet center

  • Sam A Baker

    - Make yourself at home in one of the 18 guestrooms. Next available price is on . Sam A Baker

  • Shepherd Mountain Inn

    - Make yourself at home in one of the 30 air-conditioned rooms featuring refrigerators and microwaves. Rooms have private patios. Wired and wireless internet access is complimentary, and flat-screen tel Next available price is on . Shepherd Mountain Inn

  • Super 8 by Wyndham Bonne Terre

    - Make yourself at home in one of the 40 guestrooms. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with shower/ Next available price is on . Super 8 by Wyndham Bonne Terre

  • Super 8 by Wyndham Charleston/Sikeston East MO

    - Make yourself at home in one of the 60 air-conditioned rooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available Next available price is 55.72 on Sept. 18, 2025. Super 8 by Wyndham Charleston/Sikeston East MO

  • Super 8 by Wyndham Farmington

    - Make yourself at home in one of the 62 guestrooms featuring microwaves and LCD televisions. Complimentary wireless internet access keeps you connected, and digital programming is available for your en Next available price is 54.84 on Sept. 17, 2025. Super 8 by Wyndham Farmington

  • Super 8 by Wyndham Kennett

    - Make yourself at home in one of the 53 guestrooms featuring refrigerators. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Privat Next available price is 60.80 on Sept. 17, 2025. Super 8 by Wyndham Kennett

  • Super 8 by Wyndham Perryville

    - Make yourself at home in one of the 64 air-conditioned rooms featuring refrigerators and LED televisions. Complimentary wireless internet access keeps you connected, and digital programming is availab Next available price is 76.71 on Sept. 18, 2025. Super 8 by Wyndham Perryville

  • Super 8 by Wyndham Pevely

    - Make yourself at home in one of the 63 air-conditioned guestrooms. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms with Next available price is 75.57 on Sept. 17, 2025. Super 8 by Wyndham Pevely

  • Super 8 by Wyndham Poplar Bluff Missouri

    - Make yourself at home in one of the 63 guestrooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for your entert Next available price is 70.30 on Sept. 17, 2025. Super 8 by Wyndham Poplar Bluff Missouri

  • Super 8 by Wyndham Potosi

    - Make yourself at home in one of the 49 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and satellite programming is available Next available price is 50.07 on Sept. 17, 2025. Super 8 by Wyndham Potosi

  • Super 8 by Wyndham Sikeston/Miner Area

    - Make yourself at home in one of the 63 guestrooms. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have shower/tub comb Next available price is 65.23 on Sept. 17, 2025. Super 8 by Wyndham Sikeston/Miner Area

  • The Farmstead Hotel

    - Make yourself at home in one of the 36 air-conditioned rooms featuring iPod docking stations and flat-screen televisions. Your pillowtop bed comes with down comforters and premium bedding. Complimenta Next available price is on . The Farmstead Hotel

  • The Riverview

    - Make yourself at home in one of the 69 air-conditioned rooms featuring LED televisions. Your pillowtop bed comes with premium bedding. Complimentary wireless internet access keeps you connected, and s Next available price is on . The Riverview

  • Tiny Houses of French Village

    - Make yourself at home in one of the 4 guestrooms, featuring kitchenettes with refrigerators and ovens. Next available price is on . Tiny Houses of French Village

  • Town House Inn

    - Make yourself at home in one of the 21 air-conditioned rooms featuring kitchenettes with refrigerators and ovens. Flat-screen televisions with cable programming provide entertainment, while compliment Next available price is on . Town House Inn

  • Town House Inn Cape Giradreau

    - Make yourself at home in one of the 47 air-conditioned rooms featuring refrigerators and microwaves. 40-inch LED televisions with satellite programming provide entertainment, while complimentary wirel Next available price is on . Town House Inn Cape Giradreau

  • Travelodge by Wyndham Dexter

    - Make yourself at home in one of the 133 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for Next available price is 100.80 on Sept. 17, 2025. Travelodge by Wyndham Dexter

  • Triangle Inn Motel

    - Make yourself at home in one of the 17 air-conditioned rooms featuring refrigerators and microwaves. Complimentary wireless internet access is available to keep you connected. Bathrooms have complimen Next available price is on . Triangle Inn Motel

  • Urban Lofts

    - Make yourself at home in one of the 9 air-conditioned rooms featuring kitchens with full-sized refrigerators/freezers and ovens. Your memory foam bed comes with down comforters and Egyptian cotton she Next available price is on . Urban Lofts

  • Wilderness Lodge

    - Make yourself at home in one of the 26 individually decorated guestrooms. Bathrooms with shower/tub combinations are provided. Conveniences include coffee/tea makers, housekeeping is provided on reque Next available price is on . Wilderness Lodge
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68 hotels in Southeast Missouri