Hotels in Mississippi County, Missouri

  • Overview

    Mississippi County is a county located in the state of Missouri, United States of America. It is situated in the southeastern part of the state and is known for its picturesque landscapes and charming small towns. The county is surrounded by the Mississippi River and offers stunning views of the riverfront, making it a perfect destination for nature lovers and outdoor enthusiasts.

  • When to visit

    The best time to visit Mississippi County is during the spring and fall seasons when the weather is mild and pleasant. Spring offers blooming flowers and rejuvenated landscapes, while fall brings vibrant foliage colors, making the county even more picturesque.

  • Reasons to Visit

    There are several compelling reasons to visit Mississippi County. The county is famous for its rich history and cultural heritage, with many historical sites and landmarks to explore. Visitors can experience the county's unique blend of Southern hospitality and Midwestern charm through its friendly communities and welcoming locals. Additionally, Mississippi County is an ideal destination for fishing and boating enthusiasts, as the Mississippi River provides ample opportunities for recreational activities.

  • Nearby Attractions

  • Charleston Historic District

    The Charleston Historic District is a must-visit attraction in Mississippi County. It is listed on the National Register of Historic Places and showcases a remarkable collection of well-preserved historic buildings and structures. Visitors can take a leisurely stroll through the district and admire the exquisite architecture and southern charm of the area.
  • Big Oak Tree State Park

    Situated along the Mississippi River, Big Oak Tree State Park is a natural wonderland that offers breathtaking scenic beauty. The park is home to the largest state-owned tree in Missouri, which is approximately 330 years old and stands over 148 feet tall. Visitors can enjoy hiking trails, birdwatching, and picnicking amidst the serene surroundings of the park.
  • Blytheville Main Street

    Blytheville Main Street is a vibrant downtown district in Mississippi County. It is known for its quaint shops, delicious dining options, and lively atmosphere. Visitors can explore the unique boutiques, enjoy local cuisine, and immerse themselves in the friendly community spirit of Blytheville.
  • Hotels

  • Eagle Inn Charleston

    - Make yourself at home in one of the 19 guestrooms featuring refrigerators and microwaves. Complimentary wireless internet access keeps you connected, and cable programming is available for your entert Next available price is on . Eagle Inn Charleston
  • Quality Inn Charleston - Sikeston

    - Make yourself at home in one of the 40 guestrooms featuring microwaves and LCD televisions. Complimentary wired and wireless internet access keeps you connected, and cable programming provides enterta Next available price is 67.82 on Sept. 17, 2025. Quality Inn Charleston - Sikeston
  • Super 8 by Wyndham Charleston/Sikeston East MO

    - Make yourself at home in one of the 60 air-conditioned rooms featuring refrigerators and LCD televisions. Complimentary wireless internet access keeps you connected, and cable programming is available Next available price is 56.05 on Sept. 17, 2025. Super 8 by Wyndham Charleston/Sikeston East MO

3 hotels in Mississippi County